Oral and parenteral preexposure prophylaxis (PrEP) to prevent HIV in people at risk

A systematic review of clinical effectiveness and safety with assessment of organisational, economic, patients/social, ethical and legal elements
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Project Lead: Inanna Reinsperger
Authors: Mirjana Huic (first author; HTA/EBM Center, Croatia), Inanna Reinsperger (second author; AIHTA)
Publication: March 2023
Language: English (with German summary)

Preexposure prophylaxis (PrEP) is an antiretroviral therapy-based HIV prevention strategy to prevent HIV infection in people who have not been infected with the virus but are at high risk of infection. The report aimed to provide an update evidence synthesis based on a systematic literature search regarding the effectiveness and safety of in the EU and/ or US approved oral and parenteral PrEP pharmaceutical to prevent HIV infection in populations at risk. Additionally, the report addressed organisational, economic, patient/social, ethical and legal aspects to support evidence-based decision-making process on PrEP in Austria.

 

AIHTA Project Report No. 152