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Covid-19: HSS/ Horizon Scanning Living Document (v04 July 2020), Report & Appendix
The establishment of a HSS/ Horizon Scanning System for Covid19 interventions has the intentions of informing health policy makers at an early stage which interventions (vaccinations and drugs) are currently undergoing clinical trials and to monitor them over the next few months in order to support evidence-based purchasing if necessary. The products are monitored with regard to the status of the clinical studies up to approval and finally evaluated for their benefit and harm.
All work steps are conducted in close international (European) cooperation.
Publication: Policy Brief No. 002: http://eprints.aihta.at/1234/
Contact: Claudia Wild
Update PET/PET-CT evidence for need based planning in the area of oncology
Since the 1990s, the imaging technique Positron Emission Tomography (PET) has been widely used. In recent years, hardly any other technology has been examined as frequently as PET diagnostics by Health Technology Assessment Institutions. The aim of the present update was to identify oncological indications for which the use of PET/PET-CT is recommended or explicitly not recommended by relevant societies and in evidence-based guidelines. A total of 37 evidence-based guidelines were identified regarding the use of PET for oncological indications. In the case of four oncological indications, a positive recommendation regarding the use of PET could be identified. In contrast, for eight indications a restricted use was recommended. No evidence in favour of PET examinations was identified for six indications, and for seven indication there was no, too little or inconclusive (controversial) evidence available. Just in a scarcity of instances an overall recommendations for the application of PET as a primary or standard diagnostic procedure was issued in the update 2020. In general, the present summarised evidence of guidelines can support appropriate health care service provision in Austrian hospitals.
Publication: AIHTA Policy Brief No.: 003: http://eprints.aihta.at/1249/
Contact: Nicole Grössmann
Horizon Scanning in Oncology - Fact Sheets
We are pleased to introduce our four new HSO Fact Sheets.
Fact Sheet No. 11 (Mai 2020)
Maintenance olaparib (Lynparza®) for the treatment of patients with germline BRCA-mutated metastatic pancreatic cancer
Fact Sheet No. 12 (Mai 2020)
Alpelisib (Piqray®) plus fulvestrant for PIK3CA-mutated, hormone receptor–positive advanced breast cancer
Fact Sheet No. 13 (Mai 2020)
Entrectinib (Rozlytrek®) for the treatment of patients whose solid tumours have a NTRK gene fusion, or patients with ROS1-positive advanced NSCLC
Covid-19: HSS/ Horizon Scanning Living Document (v03 June 2020)
The establishment of a HSS/ Horizon Scanning System for Covid19 interventions has the intentions of informing health policy makers at an early stage which interventions (vaccinations and drugs) are currently undergoing clinical trials and to monitor them over the next few months in order to support evidence-based purchasing if necessary. The products are monitored with regard to the status of the clinical studies up to approval and finally evaluated for their benefit and harm.
All work steps are conducted in close international (European) cooperation.
Publication: Policy Brief No. 002: http://eprints.aihta.at/1234/
Contact: Claudia Wild
Proton and carbon ion therapy – an update on indications
Worldwide, 82 particle therapy facilities are currently in clinical operation; further 37 centers are under construction or in planning. This means that the number of centres worldwide has more than doubled since 2013. In Europe alone, 27 centres are currently operational (2013: 14). With such a large number of treatment centers, it should be assumed that the underlying clinical evidence on patient benefit is convincing. The update of the LBI-HTA report 2013 has the task to give an overview of secured indications as well as indications that are only recommended under clinical research. Only a hand search for HTA reviews and systematic reviews was conducted. The identified reviews articulate in unison that the available - mostly retrospective - studies are of low quality and insufficient to make conclusive statements on the added value of proton or carbon ion therapy. Only a few indications are recommended for proton or carbon ion therapy (chordomas and chondrosarcomas, uveamelanoma, pediatric tumors in the base of the skull, brain and head and neck tumors) to avoid secondary tumors. Further indications, with curative intention and non-metastatic, are only recommended under conditions of prospective clinical studies.
Publication: AIHTA Policy Brief No.: 004: http://eprints.aihta.at/1245/
Contact: Claudia Wild
Horizon Scanning in Oncology - Fact Sheets
We are pleased to introduce our four new HSO Fact Sheets.
Fact Sheet No. 7 (April 2020)
Encorafenib (Braftovi®) in combination with cetuximab for the treatment of adult patients with metastatic colorectal cancer (mCRC) with a BRAF V600E mutation
Fact Sheet No. 8 (April 2020)
Cabazitaxel Accord for the treatment of patients with metastatic castration resistant prostate cancer (mCRPC) previously treated with a docetaxel containing regimen
Fact Sheet Nr. 9 (April 2020)
Daratumumab (Darzalex®) in a new pharmaceutical form associated with a new strength and a new route of administration for the treatment of multiple myeloma
Fact Sheet No. 10 (April 2020)
Glasdegib (Daurismo®) with low-dose cytarabine (LDAC) in patients with newly diagnosed acute myeloid leukaemia (AML)
Covid-19: HSS/ Horizon Scanning Living Document (v02 May 2020)
The establishment of a HSS/ Horizon Scanning System for Covid19 interventions has the intentions of informing health policy makers at an early stage which interventions (vaccinations and drugs) are currently undergoing clinical trials and to monitor them over the next few months in order to support evidence-based purchasing if necessary. The products are monitored with regard to the status of the clinical studies up to approval and finally evaluated for their benefit and harm.
All work steps are conducted in close international (European) cooperation.
Publication: Policy Brief No. 002: http://eprints.aihta.at/1234/
Contact: Claudia Wild
Covid-19: HSS/ Horizon Scanning Living Document (v01 April 2020), Report & Appendix
The establishment of a HSS/ Horizon Scanning System for Covid19 interventions has the intentions of informing health policy makers at an early stage which interventions (vaccinations and drugs) are currently undergoing clinical trials and to monitor them over the next few months in order to support evidence-based purchasing if necessary.
Based on international sources (information gathered by the WHO, preliminary work by other international institutions, publications) first selective searches by means of searches in study registries are carried out for information on clinical studies in humans and the state of research. Thereafter “vignettes” (short descriptions) are developed for those products that are already in an "advanced" stage. Subsequently, the products are monitored with regard to the status of the clinical studies up to approval and finally evaluated for their benefit and harm.
All work steps are conducted in close international (European) cooperation.
Publication: Policy Brief No. 002: http://eprints.aihta.at/1234/
Contact: Claudia Wild
Health Services Research in Oncology Part I: End-of-Life Care
Real-world data can provide information on the quality of health care and can inform health care system decisions. The present data analysis was focusing on the health care at the end of life of cancer patients, based on Austrian data (2012 to 2016) from all nine federal states. In the period under review, 283,228 persons with cancer diagnoses were admitted to a publicly financed hospital. Of these, about 29% (80,818) persons died. The proportion of patients who died in the inpatient sector was homogeneous across Austria (~61%) with the exception of Vienna. About 13% of deceased patients were admitted to the hospital two days before their death. With regard to the analysis of special oncological treatments (radiotherapy, chemotherapy and monoclonal antibodies) within 30 days before death, slight variabilities could be observed across the Austrian federal states.
Publication: LBI-HTA Project report No. 127: http://eprints.aihta.at/1233
Contact: Nicole Grössmann
Update 12 months follow-up: Nusinersen in spinal muscular atrophy ("late onset") in children and adolescents aged 6 years and more
In June 2017, Nusinersen (Spinraza®) was approved broadly – for all SMA Typologies (despite lack of evidence) – by the European Medicines Agency (EMA) for the treatment of chromosome 5q13 (5q)-associated SMA. The question of the update presented here is which scientific evidence from clinical intervention or observational studies for the medium (or long-term) benefit of Nusinersen (Spinraza®) in children and adolescents > 6 years with SMA "late onset" (SMA 2 + 3) is available. Three publications on the question (SMA 2 + 3 with a total of 40 patients) were identified. The available evidence for medium-term (> 12 months) follow-up data comes from a single prospective sponsor-funded ISIS CS12 study, as well as from a small retrospective study (of poor quality). Even after more than two years after the approval of Nusinersen, the evidence for this patient population is of extremely low quality, lacking validity.
Publication: Policy Brief No. 1: http://eprints.aihta.at/1228/
Contact: Claudia Wild
