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                                  Adobestock-329115246-von-mike-fouque-klein1
                                  ©Mike Fouque

                                  Covid-19: HSS/ Horizon Scanning Living Document (v02 May 2020)

                                  The establishment of a HSS/ Horizon Scanning System for Covid19 interventions has the intentions of informing health policy makers at an early stage which interventions (vaccinations and drugs) are currently undergoing clinical trials and to monitor them over the next few months in order to support evidence-based purchasing if necessary. The products are monitored with regard to the status of the clinical studies up to approval and finally evaluated for their benefit and harm.

                                  All work steps are conducted in close international (European) cooperation.

                                  Publication: Policy Brief No. 002: http://eprints.aihta.at/1234/
                                  Contact: Claudia Wild

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                                  Adobestock-329115246-von-mike-fouque-klein2
                                  ©Mike Fouque

                                  Covid-19: HSS/ Horizon Scanning Living Document (v01 April 2020), Report & Appendix

                                   The establishment of a HSS/ Horizon Scanning System for Covid19 interventions has the intentions of informing health policy makers at an early stage which interventions (vaccinations and drugs) are currently undergoing clinical trials and to monitor them over the next few months in order to support evidence-based purchasing if necessary.

                                  Based on international sources (information gathered by the WHO, preliminary work by other international institutions, publications) first selective searches by means of searches in study registries are carried out for information on clinical studies in humans and the state of research.  Thereafter “vignettes” (short descriptions) are developed for those products that are already in an "advanced" stage.  Subsequently, the products are monitored with regard to the status of the clinical studies up to approval and finally evaluated for their benefit and harm.

                                  All work steps are conducted in close international (European) cooperation.

                                  Publication: Policy Brief No. 002: http://eprints.aihta.at/1234/
                                  Contact: Claudia Wild

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                                  Fotolia-45417819-von-paulista1
                                  ©Paulista

                                  Health Services Research in Oncology Part I: End-of-Life Care

                                  Real-world data can provide information on the quality of health care and can inform health care system decisions. The present data analysis was focusing on the health care at the end of life of cancer patients, based on Austrian data (2012 to 2016) from all nine federal states. In the period under review, 283,228 persons with cancer diagnoses were admitted to a publicly financed hospital. Of these, about 29% (80,818) persons died. The proportion of patients who died in the inpatient sector was homogeneous across Austria (~61%) with the exception of Vienna. About 13% of deceased patients were admitted to the hospital two days before their death. With regard to the analysis of special oncological treatments (radiotherapy, chemotherapy and monoclonal antibodies) within 30 days before death, slight variabilities could be observed across the Austrian federal states.

                                  Publication: LBI-HTA Project report No. 127: http://eprints.aihta.at/1233
                                  Contact: Nicole Grössmann

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                                  ©vlntn

                                  Update 12 months follow-up: Nusinersen in spinal muscular atrophy ("late onset") in children and adolescents aged 6 years and more

                                  In June 2017, Nusinersen (Spinraza®) was approved broadly  – for all SMA Typologies (despite lack of evidence) –  by the European Medicines Agency (EMA) for the treatment of chromosome 5q13 (5q)-associated SMA. The question of the update presented here is which scientific evidence from clinical intervention or observational studies for the medium (or long-term) benefit of Nusinersen (Spinraza®) in children and adolescents > 6 years with SMA "late onset" (SMA 2 + 3) is available. Three publications on the question (SMA 2 + 3 with a total of 40 patients) were identified. The available evidence for medium-term (> 12 months) follow-up data comes from a single prospective sponsor-funded ISIS CS12 study, as well as from a small retrospective study (of poor quality). Even after more than two years after the approval of Nusinersen, the evidence for this patient population is of extremely low quality, lacking validity.

                                  Publication: Policy Brief No. 1: http://eprints.aihta.at/1228/
                                  Contact: 
                                  Claudia Wild

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                                  Fotolia-45417819-von-paulista
                                  ©Paulista

                                  Health Services Research in Oncology: Patients with Non-Small Cell Lung Cancer Treated with Anti-PD-1/PD-L1 Therapy in Real-World Practice. A Pilot Project in Cooperation with Tirol Kliniken GmbH & KAGes

                                  Experience in routine clinical practice may differ from that seen in a controlled clinical trial. Although randomised clinical trials (RCTs) are considered to be the standard for generating clinical evidence, they lack generalisability to real-world evidence due to selected patient populations (strict and complex enrolment criteria). Therefore, the use of real-world evidence (RWE) to evaluate the effectiveness and safety of medical interventions is gaining interest. As there is limited evidence regarding the real-world effectiveness of immunotherapy in Austria, we conducted a retrospective pilot study in six Austrian hospitals to present data on patient characteristics, effectiveness and safety from real-world practice in an NSCLC population treated with anti-PD-1/PD-L1 monotherapy.

                                  Publication: LBI-HTA Projektbericht Nr. 126: to be published soon
                                  Contact: Claudia Wild

                                  Fotolia-35183588-von-vilevi
                                  ©VILevi

                                  Minimum volume standards for quality assurance in day surgery

                                  A possible measure for quality assurance in day surgery is minimum volume standards (MVSs). While the majority of research in this context observes a positive relationship between volume and outcome in the form of statistical correlation, the data availability on surgery specific and evidence-based minimum volume thresholds is low. Aims of the present report were to show the fundamentals of the MVSs theory, to illustrate possible internationally implemented MVSs frameworks in day surgery, and (in the course of a systematic review) to examine whether MVVs for specific day surgeries lead to better results in terms of efficacy and safety.

                                  Publication: LBI-HTA Project report No. 125: https://eprints.aihta.at/1225/
                                  Contact: Michal Stanak, Christoph Strohmaier

                                   

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                                  Adobestock-242506134-von-have-a-nice-day
                                  ©Have a nice day

                                  POCT/ Point of Care Tests: D-Dimer and Troponin

                                  Troponin and D-dimer point of care tests can be used to aid the diagnosis of patients with symptoms suggestive of suspected acute coronary syndrome and venous thromboembolism respectively. Potential advantages of point of care tests include faster turnaround time, reduced length of stay and reduced unnecessary hospitalisation/further testing. This report aimed at evaluating the clinical benefit of these two point of care diagnostics in various settings. Two overview of reviews, two guideline synopsis and interviews with experts were hereby carried out.

                                  Publication: LBI-HTA Project report 124: https://eprints.aihta.at/1224/
                                  Contact: Gregor Goetz

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                                  Adobestock-137738915-von-rawpixel-com
                                  ©Rawpixel.com

                                  Cervical Carcinoma Prevention - Implementation of an HPV screening test in the early detection of cervical cancer in Austria

                                  Cervical cancer screening has been revolutionized by the discovery that nearly all cervical cancer diseases are caused by persistent infection with human (high-risk) papillomaviruses (HPV). Along with this, the development of new HPV-based test systems internationally led to a change in existing cervical carcinoma screening strategies. The purpose of this report was to provide a basis for the decision to implement the HPV test in cervical carcinoma screening in Austria.

                                  Publication: LBI-HTA Project report No. 121: https://eprints.aihta.at/1223/
                                  Contact: Eva Fuchs, Sarah Wolf

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                                  Adobestock-287366133-von-robert-kneschke1
                                  ©Robert Kneschke

                                  Screening programs for children and adolescents from 6 to 18 years. Results on selected countries, Austrian screening programmes and recommendations from evidence-based guidelines

                                  This LBI-HTA report focuses on children and adolescents from 6 to 18 years and deals with 9 international screening services, 4 Austrian screening programmes and with screening and counselling recommendations from 59 evidence-based guidelines on a total of 25 diseases and risk profiles. Based on the guidelines, the report involves positive screening recommendations for 11 health threats. The country programmes resulted in consistent screenings with regard to body weight, height, dental diseases, visual and hearing disorders and mental disorders. In summary, thematic similarities between the guideline recommendations, the international practice examples and the 4 Austrian programmes were found.

                                  Publication: LBI-HTA Project report No. 123 + Addendum report: https://eprints.aihta.at/1221
                                  Contact: Roman Winkler / Inanna Reinsperger

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                                  Adobestock-88617001-von-syda-productions
                                  ©Syda Productions

                                  Rehabilitation for children and adolescents in Austria: A systematic analysis of evaluation methodologies

                                  Until a few years ago, there were no specially designed rehabilitation centres for children and adolescents in Austria, which differ from adult rehabilitation programmes with regard to the supply structure (e.g.; structural requirements or rehabilitation measures). In 2010, a need for a total of 343 beds for 11 indicator groups and an additional 50 beds for the relatives was indicated within the scope of the planning phase of the child and adolescent rehabilitation centres in four Austrian supply zones by 2020. The six newly built centres will now be evaluated on a regular basis. Therefore, the present report provides an overview of international evaluation methods and (standardised) evaluation instruments that can be used for future evaluations.

                                  Publication: LBI-HTA Projektbericht No. 122: https://eprints.aihta.at/1222

                                  Contact: Sarah Wolf, Roman Winkler

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