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This report is an update of a previous Horizon Scanning report from 2020, which identified 32 ATMPs. Since August 2020, six of these new ATMPs have been approved by the EMA and five more will be decided by 2023. According to market analyses, 535 ATMPs will be investigated in phase 1 to 3 in 2022, with a further 1,451 in preclinical stages. Coagulation factor VIII (haemophilia A) remains the most common target for non-oncology indications and coagulation factor IX (haemophilia B) has risen to become the second most common indication.

The treatment of diabetes mellitus is individually tailored to achieve freedom from symptoms and avoid acute complications and serious secondary diseases. Telemedical diabetes care programs can be supported by digital health applications and may be beneficial to improve diabetes care. This report provides an overview of Austrian telemedicine activities and a systematic review of evaluation methods and evidence of potential health care effects.

Prenatal screening and diagnostic tests include First Trimester Screening/Combined Test, non-invasive prenatal test (NIPT), invasive (diagnostic) tests and ultrasound screening for fetal anomalies in the second trimester. Whether and in what form these tests are offered and financed to pregnant women varies considerably between countries. This policy brief provides an overview of country strategies for integrating the tests into antenatal care and their (public) financing in 6 selected European countries (DE, CH, NL, UK, NO, IT).

CAR-T cell-therapies are commonly indicated as „transformative“ therapies referring to the huge expectations associated with them since their market approval in 2017 (USA) and 2018 (Europe). Due to the hope, but also the enormous prices a horizon scanning (HS) document was first published in 2020 to support budget planning in hospitals. In 2020 13 CAR-T cell-therapies in advanced stages were identified. Of these, in addition to Yescarta® and Kymriah®, that were already approved at that time, three further therapies have since been approved by the European Medicines Agency (EMA) between 8/ 2020 and 03/2022: Tecartus® (2020), Abcema® (2021) and Breyanzi® (2022).

This HS document updates the earlier report by surveying the status of the ten therapies already described in 2020 and adding additional therapies that have since then reached a later phase of clinical testing. Within the next year 2023 one new CAR-T cell-Therapy for multiple myeloma will eventually be approved, but further development can be expected with the extension of the approved CAR-T cell-therapies towards earlier lines of therapy and new indications.