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AIHTA is an acadmic non-profit institute. At our website we wish to present our research and give support for health care decision-making. Here all of our reports are available for free. For further information please contact the AIHTA team.
In the News section you will find our most recent publications: newsletter, project-reports etc. Previous reports you might find via Research areas, Research projects and Repository.
Announcement
Horizon Scanning in Oncology - Fact Sheets
We are pleased to introduce you five new Fact Sheets.
Fact Sheet No. 191 (September 2024)
Daratumumab (Darzalex®) with bortezomib, lenalidomide and dexamethasone for the treatment of newly diagnosed multiple myeloma (MM)
Fact Sheet No. 192 (September 2024)
Serplulimab (Hetronifly®) with carboplatin and etoposide for the first?line treatment of extensive?stage small cell lung cancer (ES-SCLC)
Fact Sheet No. 193 (September 2024)
Mirvetuximab soravtansine (Elahere®) for the treatment of adults with folate receptor-alpha (FR?) positive epithelial ovarian, fallopian tube and primary peritoneal cancer
Fact Sheet No. 194 (September 2024)
Pembrolizumab (Keytruda®) with chemoradiotherapy (CRT) for the treatment of FIGO 2014 Stage III - IVA locally advanced cervical cancer
Fact Sheet No. 195 (September 2024)
Pembrolizumab (Keytruda®) for the treatment of adults with endometrial carcinoma
Announcement
Threshold values in health economic evaluations and decision-making
Healthcare systems worldwide face the challenge of optimising resource allocation and maximising health benefits through their funding decisions.
This report examines how healthcare systems approach resource allocation through incremental cost-effectiveness ration (ICER) thresholds. Through analysis of literature, policy documents, and health economic guidelines from various countries, the research explores theoretical foundations and practical applications of these thresholds. The findings reveal significant variations in threshold implementation across countries and show important relationships between thresholds and health system outcomes. The research also identifies key factors for implementation. This report offers insights into how threshold implementation can enhance healthcare system transparency and efficiency when adapted to national contexts.
Publication: HTA Project Report No. 163: https://eprints.aihta.at/1549/
Contact: Christoph Strohmaier
Announcement
Artificial Intelligence in health care with a focus on hospitals: Methodological considerations for Health Technology Assessment. A Scoping Review.
Artificial Intelligence (AI) in healthcare comprises machine-based systems designed to imitate human cognitive abilities and is increasingly important in digital health technologies. An analysis of 51 Health Technology Assessment (HTA) institutions revealed that 13 institutions published a total of five methodological documents and 30 HTA reports, primarily focusing on diagnostic and screening applications (27/30), which mainly serve as support tools and require medical personnel decision-making.
The analysis shows that standard HTA methods can serve as a starting point for evaluation, but AI-specific considerations are required for technical, ethical, and organisational aspects as well as implementation monitoring. The latter is particularly important as algorithms can change and need regular evaluation. Regulatory compliance requires adherence to the EU AI Act, Medical Device Regulation and General Data Protection Regulation. A mature digital infrastructure with high interoperability is considered a fundamental prerequisite for successful implementation.
Publication: HTA Project Report No. 164: https://eprints.aihta.at/1546/
Contact: Michaela Riegelnegg
Announcement
Strategies for reducing weight stigmatisation towards people with overweight or obesity in the healthcare system
Every second person who is overweight or obese is generally affected by stigmatisation due to their body weight. The healthcare sector is cited as one of the most common causes. As a result, the affected patients may receive incorrect or no diagnoses and therapies, avoid examinations and suffer health consequences such as further weight gain. Through a systematic literature search, various guideline-based recommendations for reducing weight stigma towards overweight and obese people in healthcare settings were identified. Further, available evidence for investigated interventions was analysed.
Publication: HTA Project Report No. 160: https://eprints.aihta.at/1547/
Contact: Sarah Wolf
Announcement
Oncological Breast Cancer Care in Selected European Countries- Cross-sectoral cancer care models
The increasing incidence and prevalence of cancer, particularly breast cancer, presents substantial challenges for the Austrian healthcare system. The current hospital-centred care delivery model contributes to escalating costs and suboptimal resource utilisation.
A comprehensive analysis of cancer care models across six European countries (Austria [AT], Germany [DE], Denmark [DK], Sweden [SE], Netherlands [NL], Belgium [BE]) was conducted through structured literature review, expert consultations (n=17), and data synthesis, focusing specifically on breast cancer care. Analysis of healthcare infrastructures and cross-sectoral care approaches throughout the patient journey identified three distinct models: centralised specialist models (AT, BE, DK) characterised by highly specialised centres with strict volume requirements; decentralised care (DE) featuring distributed hospital structures in the in- and outpatient setting; and network-based integrated care (NL, SE) combining specialist centres with regional care delivery. These models demonstrate considerable variations in their utilisation of inpatient, outpatient, and home-based care services. While these models reflect varying degrees of centralisation and specialisation, they all aim to ensure high-quality care through regulation, accreditation and collaboration, with countries combining elements of different models based on their national cancer strategy and healthcare infrastructure.
For Austria, implementing a gradual transition towards a more decentralised or network-based model could potentially alleviate pressure on hospital resources while enhancing quality of care. However, successful implementation necessitates appropriate infrastructure, qualified healthcare professionals, and effective cross-sectoral coordination. Key challenges include addressing workforce shortages and overcoming fragmented data integration across healthcare sectors.
Publication: HTA Project Report No. 162: https://eprints.aihta.at/1545/
Contact: Nicole Grössmann-Waniek
Newsletter
Announcement
Mental health screening of adults in primary care
With approximately one in five Austrian adults affected by mental illness annually, primarily depression (10%), anxiety disorders (7%), and substance use disorders (12%), screening in primary care settings could help identify and treat affected individuals early. Based on systematic reviews and evidence-based guidelines, this report analyses the evidence for mental health screening in primary care, identifies available screening tools, and discusses the requirements for implementing screening.
Publication: HTA Project Report No. 159: https://eprints.aihta.at/1544
Contact: Julia Kern
Newsletter
Announcement
Horizon Scanning in Oncology - Fact Sheets
We are pleased to introduce you seven new Fact Sheets.
Fact Sheet Nr. 184 (July 2024)
Toripalimab (Loqtorzi®) in combination with cisplatin and gemcitabine for the first-line treatment of recurrent, not amenable to surgery or radiotherapy, or metastatic nasopharyngeal carcinoma (NPC)
Fact Sheet Nr. 185 (July 2024)
Toripalimab (Loqtorzi®) with cisplatin and paclitaxel for the first-line treatment of unresectable advanced, recurrent, or metastatic oesophageal squamous cell carcinoma (OSCC)
Fact Sheet Nr. 186 (July 2024)
Zolbetuximab (Vyloy®) with chemotherapy for the first-line treatment of locally advanced unresectable or metastatic HER2?negative gastric or gastro-oesophageal junction (GEJ) adenocarcinoma
Fact Sheet Nr. 187 (July 2024)
Encorafenib (Braftovi®) in combination with binimetinib (Mektovi®) for the treatment of advanced non-small cell lung cancer (NSCLC)
Fact Sheet Nr. 188 (July 2024)
Pembrolizumab (Keytruda®) with enfortumab vedotin (Padcev®) for the first-line treatment of unresectable or metastatic urothelial carcinoma
Fact Sheet Nr. 189 (July 2024)
Amivantamab (Rybrevant®) in combination with carboplatin and pemetrexed for the treatment of advanced non-small cell lung cancer (NSCLC)
Fact Sheet Nr. 190 (July 2024)
Atezolizumab (Tecentriq®) as monotherapy for the first-line treatment of advanced NSCLC