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Welcome to the homepage of AIHTA!

AIHTA is an acadmic non-profit institute. At our website we wish to present our research and give support for health care decision-making. Here all of our reports are available for free. For further information please contact the AIHTA team.

In the News section you will find our most recent publications: newsletter, project-reports etc. Previous reports you might find via Research areas, Research projects and Repository.

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Announcement

Horizon Scanning in Oncology - Fact Sheets

We are pleased to introduce our fivenew HSO Fact Sheets.

Fact Sheet No. 72 (January 2022)
Enfortumab vedotin (Padcev®) as monotherapy for the treatment of patients with locally advanced or metastatic urothelial cancer

Fact Sheet No. 73 (January 2022)
Tepotinib (Tepmetko®) as monotherapy for the treatment of patients with advanced non-small cell lung cancer (NSCLC)

Fact Sheet No. 74 (January 2022)
Pembrolizumab (Keytruda®) as monotherapy for the adjuvant treatment of renal cell carcinoma (RCC)

Fact Sheet Nr. 75 (January 2022)
Lorlatinib (Lorviqua®) as monotherapy for the treatment of anaplastic lymphoma kinase (ALK) positive advanced non-small cell lung cancer (NSCLC)

Fact Sheet No. 76 (January 2022)
Tegafur/gimeracil/oteracil (Teysuno®) for the treatment of metastatic colorectal cancer

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Note: this content is only available in German.

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Announcement

Covid-19: HSS/ Horizon Scanning Living Document (v19 December 2021/January 2022)

The establishment of a HSS/ Horizon Scanning System for Covid19 interventions has the intentions of informing health policy makers at an early stage which interventions (vaccinations and drugs) are currently undergoing clinical trials and to monitor them over the next few months in order to support evidence-based purchasing if necessary. The products are monitored with regard to the status of the clinical studies up to approval and finally evaluated for their benefit and harm.

All work steps are conducted in close international (European) cooperation.

Publications:

Policy Brief No. 002: http://eprints.aihta.at/1234/

Contact: Claudia Wild

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Announcement

>=12 Month Follow-Up of Patients with Spinal Muscular Atrophy (SMA) treated with Spinraza®, Zolgensma® or Combination Therapies

Since 2017, the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have approved three drugs for the treatment of SMA. Results of the pivotal trials showed clinically meaningful improvements (MCID) in motor skills in SMA type 1 (especially those with early treatment initiation and ?2 SMN2 copies), as well as a stabilisation of health status in SMA type 2 to 4 patients. In SMA type 1 patients, while motor skills improved, no changes (sometimes even a deterioration) in the need for ventilation and nutritional support could be observed. The present report aims to synthesize the evidence on mid- and long-term (? 12 months) follow-up of the approved drugs as monotherapies or as combination therapies.

Twenty-two observational studies were included for analysing mid- and long-term outcomes. The included studies reported on 840 SMA patients, of which 289 SMA type 1 patients and 521 SMA type 2 to 4 patients were treated with nusinersen, only 12 SMA type 1 patients with onasemnogene abeparvovec and 18 SMA type 1 patients received a combination therapy.

Publication: Policy Brief No. 001, 1. Update: https://eprints.aihta.at/1352
Contact: Judit Erdös, Claudia Wild

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Announcement

The economic and societal dimension of parental mental illness

Children and adolescents from so-called ‘parents with a mental illness’ have a potentially increased risk of developing negative (health) consequences on the way to their adulthood. One option to mitigate or even prevent negative consequences are family-oriented intervention programmes with social support systems. Gaps in health economic knowledge is a barrier to grasp the overall benefit of these programmes. The report is intended to serve as a source for researchers in order to conduct sound impact assessments of family-oriented intervention programmes and to raise awareness in policy makers about the economic and societal dimensions of mental illness in families.

Publication: HTA Project Report No. 142: https://eprints.aihta.at/1351/
Contact: Christoph Strohmaier

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Announcement

National strategies and programmes for preventing and managing non-communicable diseases in selected countries

Non-communicable diseases (NCDs) are the leading cause of death worldwide and are responsible for a high burden of disease. Many countries have developed national strategies for the management and prevention of NCDs in order to improve the care of chronically ill people or to prevent NCDs. This report aims to provide an overview of national NCD strategies from selected countries and their implementation as well as to summarise evaluation findings on specific programmes. The focus was on chronic respiratory and cardiovascular diseases, diabetes and depression.

Publication: HTA Project Report No. 139: https://eprints.aihta.at/1349/
Contact: Lucia Gassner, Inanna Reinsperger

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Announcement

Process and evaluation of digital health applications in the context of “symptom-checkers”

Digital health applications (DiGAs) are increasingly using diagnostic and therapeutic algorithms. However, for the majority of currently available DiGAs, there is limited evidence on the medical or organizational benefit. Based on a suggested evaluation process for DiGAs outlined by AIHTA (Project report 2020: “Framework for reimbursement decisions of digital health technologies”), the proposed process for an evidence-based evaluation has been further refined and applied in a sample evaluation of a DiGA from the group of the so-called “symptom-checkers”.

Publication: HTA Projekt Report No. 141: https://eprints.aihta.at/1348/
Contact: Reinhard Jeindl

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