Logo_AIHTA
  • Deutsch
  • Contact
    • Imprint
      • Privacy Notice
        • Newsletter
          • Sitemap
            Menu_button
            • News
              • About us
                • Research areas
                  • Research Projects
                    • Publications
                      • Search
                        • Synopsis of current research projects
                          • Synopsis of completed research projects
                            • Decision Support Documents for the Austrian Appraisal Board
                              • HTA-Information Service Rapid Reviews
                                • Horizon Scanning in Oncology – Prioritisation of new and emerging oncologic drugs
                                  • Horizon Scanning of Medicines - Reports and Fact Sheets
                                    • Horizon Scanning in Oncology – support for a budget-impact-calculation
                                      • Evaluation of individual medical procedures - Reports
                                        • All projects in an overview
                                          • Supervised Master's Theses
                                            Video
                                            Video: What is HTA?    
                                            • Home
                                            • Research Projects
                                            • Synopsis of completed research projects
                                            • Cervical cancer screening: p16/KI-67 Dual Stain test (CINtec® PLUS) in the triage of equivocal results or mild to moderate dysplasia in pap cytology

                                            Cervical cancer screening: p16/KI-67 Dual Stain test (CINtec® PLUS) in the triage of equivocal results or mild to moderate dysplasia in pap cytology

                                            Papsmear
                                            Research area: High tech medicine

                                            Project leaders: Ingrid Zechmeister-Koss

                                            Duration: April 2013 - September 2013
                                            Publicationen:
                                            - HTA project report No. 72: https://eprints.aihta.at/1009/
                                            - Kisser A, Zechmeister-Koss I. A systematic review of p16/Ki-67 immuno-testing for triage of low grade cervical cytology. BJOG 2014; DOI: 10.1111/1471-0528.13076

                                            Language: German

                                            Each year around 30000 women in Austria receive a PAPIII or PAPIIID cytology result during routine cervical cancer screening. Roughly equivalent to ASC-US or LSIL cytology according to Bethesda classification, this result means that equivocal cell anomalies or mild to moderate dysplasia were detected in their pap smear. The risk of progression to cancer of these results is unclear and requires further diagnostic investigation: this induces emotional stress to the patients and causes a high number of unnecessary procedures, including biopsies and conisations.

                                            The p16/KI-67 Dual Stain test (CINtec® PLUS) claims to detect virally induced oncogenic molecular changes in the cell through the immune cytochemical double staining of the tumour suppressor gene p16INK4a and the proliferation marker Ki-67 and thereby to improve the triage of women with equivocal cytological results.

                                            We have conducted a systematic review of the studies assessing utlity of the p16/Ki-67 Dual Stain test in the triage of equivocal or mild to moderate dysplasia results in cervical cancer screening. We could not identify any studies assessing clinical outcomes such as mortality or morbidity and only one high quality study assessing diagnostic accuracy of the test: the evaluation of the clinical utility of the test was therefore not possible. Consequently the test was not recommended for inclusion in the benefits catalogue of public health insurances.

                                             

                                            • News
                                              • Job advertisement: Assistant Finance Department/HR/ Science
                                                • Job advertisement in AIHTA - Job advertisement: Senior researcher
                                                  • Announcements
                                                    • Events
                                                      • Newsletter
                                                        • Press release on our reports
                                                          • Press photos
                                                          • About us
                                                            • Evaluation
                                                              • History
                                                                • Methods
                                                                  • Team
                                                                    • Shareholder & organization chart
                                                                      • Stakeholder involvement
                                                                        • Press clippings
                                                                        • Research areas
                                                                          • Oncology
                                                                            • High tech medicine
                                                                              • Rehabilitation and occupational therapy
                                                                                • Prevention and screening
                                                                                  • Psychological & psychiatric interventions
                                                                                    • Health economics
                                                                                      • European collaboration
                                                                                        • HTA-methods & steering instruments
                                                                                          • Complementary medicine
                                                                                          • Research Projects
                                                                                            • Synopsis of current research projects
                                                                                              • Synopsis of completed research projects
                                                                                                • Decision Support Documents for the Austrian Appraisal Board
                                                                                                  • HTA-Information Service Rapid Reviews
                                                                                                    • Horizon Scanning in Oncology – Prioritisation of new and emerging oncologic drugs
                                                                                                      • Horizon Scanning of Medicines - Reports and Fact Sheets
                                                                                                        • Horizon Scanning in Oncology – support for a budget-impact-calculation
                                                                                                          • Evaluation of individual medical procedures - Reports
                                                                                                            • All projects in an overview
                                                                                                              • Supervised Master's Theses
                                                                                                              • Publications
                                                                                                                • Repository
                                                                                                                  • HTA-Newsletter
                                                                                                                    • Annual Reports
                                                                                                                    • Search
                                                                                                                      Netzwerk
                                                                                                                      • Eunethta
                                                                                                                      • Ebm
                                                                                                                      • Inahta
                                                                                                                      • Dexhelpp
                                                                                                                      Shareholder
                                                                                                                      • Bmfg
                                                                                                                      • Sv
                                                                                                                      • Wgfond
                                                                                                                      • Noe
                                                                                                                      • Ooghfond
                                                                                                                      • Ghls
                                                                                                                      • Tirol
                                                                                                                      • Vorarlberg
                                                                                                                      • Kghfond
                                                                                                                      • Ghpf
                                                                                                                      • Burgef
                                                                                                                      • Contact
                                                                                                                        • Imprint
                                                                                                                          • Privacy Notice
                                                                                                                            • Newsletter
                                                                                                                              • Sitemap
                                                                                                                                © 2025 HTA Austria - Austrian Institute for Health Technology Assessment GmbH. Alle Rechte vorbehalten.
                                                                                                                                • Log in