News

 The establishment of a HSS/ Horizon Scanning System for Covid19 interventions has the intentions of informing health policy makers at an early stage which interventions (vaccinations and drugs) are currently undergoing clinical trials and to monitor them over the next few months in order to support evidence-based purchasing if necessary.

Based on international sources (information gathered by the WHO, preliminary work by other international institutions, publications) first selective searches by means of searches in study registries are carried out for information on clinical studies in humans and the state of research.  Thereafter “vignettes” (short descriptions) are developed for those products that are already in an "advanced" stage.  Subsequently, the products are monitored with regard to the status of the clinical studies up to approval and finally evaluated for their benefit and harm.

All work steps are conducted in close international (European) cooperation.

Real-world data can provide information on the quality of health care and can inform health care system decisions. The present data analysis was focusing on the health care at the end of life of cancer patients, based on Austrian data (2012 to 2016) from all nine federal states. In the period under review, 283,228 persons with cancer diagnoses were admitted to a publicly financed hospital. Of these, about 29% (80,818) persons died. The proportion of patients who died in the inpatient sector was homogeneous across Austria (~61%) with the exception of Vienna. About 13% of deceased patients were admitted to the hospital two days before their death. With regard to the analysis of special oncological treatments (radiotherapy, chemotherapy and monoclonal antibodies) within 30 days before death, slight variabilities could be observed across the Austrian federal states.

In June 2017, Nusinersen (Spinraza®) was approved broadly  – for all SMA Typologies (despite lack of evidence) –  by the European Medicines Agency (EMA) for the treatment of chromosome 5q13 (5q)-associated SMA. The question of the update presented here is which scientific evidence from clinical intervention or observational studies for the medium (or long-term) benefit of Nusinersen (Spinraza®) in children and adolescents > 6 years with SMA "late onset" (SMA 2 + 3) is available. Three publications on the question (SMA 2 + 3 with a total of 40 patients) were identified. The available evidence for medium-term (> 12 months) follow-up data comes from a single prospective sponsor-funded ISIS CS12 study, as well as from a small retrospective study (of poor quality). Even after more than two years after the approval of Nusinersen, the evidence for this patient population is of extremely low quality, lacking validity.