Project Lead & Author: Susanne Fasching
Publication: April 2026
Language: English (with German summary)
Anxiety and depressive disorders account for a significant proportion of the global mental health burden. Treatment challenges in antidepressant therapy have stimulated interest in adjunctive nutritional interventions, such as B vitamins, due to their role in neurobiological processes relevant to mood regulation. However, existing systematic reviews have not focused specifically on adjunctive regimens combining multiple B vitamins with antidepressants. Consequently, this systematic review aimed to evaluate the efficacy and safety of combining a vitamin B complex (>2 B vitamins) with antidepressant medication to improve symptom severity in depression and anxiety.